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Medications That Can Lead to False Positive Methamphetamine Drug Test Results

Drug tests are commonly used to screen individuals for the presence of illicit substances in their system. However, it’s important to note that these tests are not foolproof and can sometimes yield false positive results. A false positive occurs when a drug screening indicates the presence of a substance, such as methamphetamine, when in reality, the individual has not consumed the drug. One potential cause of false positive results is the presence of certain medications that can trigger a positive reading for methamphetamine. Understanding which medications can lead to false positive results is crucial for individuals undergoing drug testing to avoid unnecessary confusion and potential consequences.

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Medications Associated with False Positive Methamphetamine Results:

  1. Amphetamines and Related Stimulant Medications:
    • Medications containing amphetamines or related stimulant compounds, such as Adderall (used for ADHD), can produce false positive results for methamphetamine on drug tests. These medications have similar chemical structures to methamphetamine and can cross-react with the screening tests.
  2. Over-the-Counter Decongestants and Cold Medications:
    • Certain over-the-counter decongestants and cold medications, such as pseudoephedrine (found in products like Sudafed), can result in false positive methamphetamine readings. Pseudoephedrine is chemically similar to methamphetamine and can trigger a positive response in drug tests.
  3. Prescription Medications for Nasal Conditions:
    • Prescription medications used for nasal conditions, like nasal sprays containing levomethamphetamine (a component of some nasal decongestants), can potentially lead to false positive results for methamphetamine. The presence of levomethamphetamine can be misinterpreted as methamphetamine in drug screenings.
  4. Antidepressant and Antipsychotic Medications:
    • Some antidepressant and antipsychotic medications, such as bupropion (Wellbutrin) and certain antipsychotics (e.g., quetiapine, aripiprazole), have been reported to cause false positive methamphetamine results. However, such instances are relatively rare and require confirmation through confirmatory testing methods.

Consultation with Medical Professionals:

If you are taking any of the aforementioned medications or any other substances that might trigger a false positive methamphetamine result, it is crucial to inform the testing personnel or medical professionals conducting the drug test about your medication usage. This information can help them interpret the results accurately and potentially perform confirmatory testing to rule out false positives.

Confirmatory Testing and Additional Steps:

Overland Iop| #1 Intensive Outpatient Programs | Los Angeles Ca False-positive-drug-test.
false positive drug test

In cases where a false positive methamphetamine result is obtained, it is essential to request confirmatory testing, such as gas chromatography-mass spectrometry (GC-MS) or liquid chromatography-tandem mass spectrometry (LC-MS/MS). These methods can provide more accurate and reliable results, helping to clarify any potential false positives.

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Published: May 12, 2023

Last Updated: May 12, 2023


Natalia Golenkova

Marketing Specialist


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